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Redefining Cell Culture:The Smart Way to Replace Serum
Serum substitutes represent a major advancement in cell culture technology, offering defined or semi-defined solutions that overcome the limitations of animal-derived serum. Traditional fetal bovine serum (FBS) is poorly defined, variable in composition, and associated with contamination risks, ethical concerns, and supply-chain challenges. Serum replacements provide controlled formulations that improve reproducibility, enhance safety, and support consistent experimental and production outcomes. PAN-Biotech’s Panexin product line delivers ready-to-use serum substitutes that reduce or eliminate reliance on animal serum while meeting high regulatory and GMP standards. These formulations support reliable cell growth across diverse applications, from research to industrial bioprocessing.
Performance Guideline
In some cases successful adaptation of cells to Panexin can be achieved by choosing a different basal medium.
Basic
Basic
Panexin basic is a serum substitute that acts as a cost-effective allrounder. It only contains traces of animal-derived components (< 2 % w/v).
It can be used for the cultivation of adherent and suspension cells, such as: HEK 293, MDCK, MCF-7, U-739, MDBK
NTA
NTA
Panexin NTA is a serum substitute which only contains traces of animal-derived components (< 2 % w/v). It is optimized for the cultivation of adherent growing cells.
It supports the growth of many established cell lines, such as: L929, CHO, HAT-29, HEK 293, MDCK
CD
CD
Panexin CD is a chemically defined serum substitute. It is completely free of animal or human components and can be used for the cultivation of adherent and suspension cells.
Among others the following cell lines have been successfully cultured with
Panexin CD:
HeLa, L929, HEK 293, Vero Lymphocyte
Panexin CD is also available in GMP compliant quality.
Serum-Free Media
PAN-Biotech’s high-quality serum-free media are specifically formulated for optimized expansion of cells entirely without the need of supplementing sera. Although supplementation with serum in cell culture is common practice, it is associated with a number of disadvantages. Growing ethical concerns, a significant batch-to-batch variability and its undefined composition have led to an increasing demand on serum-free products.
- highly defined cell culture conditions
- increased reproducibility of your applications
- simplified downstream and purification processes
Serum-Free Stem Cell Media
Stem cells are particularly interesting for academic research and the development of cell therapies.
PowerStem MSC1 is an easy-to-use xeno-free medium for in vitro proliferation of human mesenchymal stem cells (hMSC). It supports long-term growth of MSCs and keeps the cells in an undifferentiated state, which allows for specifically induced differentiation into various tissues like bone or cartilage.
In addition, MSCs cultured in PowerStem MSC1 expand faster and show a significant reduction in hematopoietic cell contamination at early passages compared to serum-based media.